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comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblasticleukemia: targeted immunotherapy for acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblasticleukemia.

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract:

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acutelymphoblastic leukemia (B-ALL).This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblasticleukemia with poor prognosis.

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 518-526 doi: 10.1007/s11684-022-0958-6

Abstract: Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL).

Keywords： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvementDeeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblasticleukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 229-238 doi: 10.1007/s11684-017-0506-y

Abstract:

A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group foradult acute lymphoblastic leukemia (ALL).

Keywords： Philadelphia chromosome     acute lymphoblastic leukemia     imatinib     CALLG2008    

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Diagnosis-related Groups (DRGs)-based payment reform to bring benefits to patient care: A case study of leukemia

Zhi-Ruo ZHANG PhD, Jian-Qing MI MD, Zhao-Jun WEN MA, Sai-Juan CHEN MD, PhD, Zhu CHEN PhD, Long-Jun GU MD, Jing-Yan TANG MD, PhD, Shu-Hong SHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 8-15 doi: 10.1007/s11684-010-0018-5

Abstract: the level of reimbursement from insurance is very limited, especially for critical diseases such as leukemiaTreatments of acute promyelocytic leukemia at Rui-Jin Hospital, and childhood acute lymphoblastic leukemia

Keywords： reform     diagnosis-related groups     clinical paths     comparative effectiveness analysis     acute promyelocytic leukemia     childhood acute lymphoblastic leukemia    

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemiacells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the diseasea potentially curable type of leukemia.

Keywords： acute promyelocytic leukemia     arsenic     all-trans retinoic acid     survival    

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Article

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Engineering 2019, Volume 5, Issue 1,   Pages 150-155 doi: 10.1016/j.eng.2018.12.006

Abstract:

Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stemcell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL).Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCTdifferentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemiaThree of the six patients are currently alive without leukemia.

Keywords： Donor-derived CD19-targeted T cell infusion     Hematopoietic stem cell transplantation     B cell acute lymphoblasticleukemia     Minimal residual disease    

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 204-211 doi: 10.1007/s11684-012-0202-x

Abstract:

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely

Keywords： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 347-371 doi: 10.1007/s11684-020-0821-6

Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with

Keywords： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

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hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 304-311 doi: 10.1007/s11684-015-0400-4

Abstract: tyrosine kinase inhibitor (TKI) era, imatinib is the first-line therapy for patients with chronic myeloid leukemia

Keywords： chronic myeloid leukemia     imatinib     dasatinib     nilotinib     allogeneic hematopoietic stem cell transplantation    

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Title Author Date Type Operation

comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblasticleukemia: targeted immunotherapy for acute lymphoblastic leukemia

Journal Article

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblasticleukemia

Yinjun Lou, Yafang Ma, Chenyin Li, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Wenjuan Yu, Liping Mao, Juyin Wei, Weilei Xu, Jie Jin

Journal Article

Diagnosis-related Groups (DRGs)-based payment reform to bring benefits to patient care: A case study of leukemia

Zhi-Ruo ZHANG PhD, Jian-Qing MI MD, Zhao-Jun WEN MA, Sai-Juan CHEN MD, PhD, Zhu CHEN PhD, Long-Jun GU MD, Jing-Yan TANG MD, PhD, Shu-Hong SHEN MD, PhD,

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Journal Article

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual

Yifei Cheng,Yuhong Chen,Chenhua Yan,Yu Wang,Xiangyu Zhao,Yao Chen,Wei Han,Lanping Xu,Xiaohui Zhang,Kaiyan Liu,Shasha Wang,Lungji Chang,Lei Xiao,Xiaojun Huang

Journal Article

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Journal Article

hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Journal Article